RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiotaRS-5645는 폐 미생물총을 조절하여 SARS-CoV-2 스파이크 단백질 및 LPS에 의해 유도된 염증성 사이토카인 폭풍을 약화시킵니다Research Paper Published on 2021-07-252022-09-10 Journal: International Journal of Biological Sciences [Category] SARS, 바이오마커, [키워드] 16S rRNA 4-(thiophen-3-yl)-1-(p-tolyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone (RS-5645) abundance Activation addition alveolar alveoli Amino acid amino acid metabolism Analysis attenuate biogenesis cause of death CD11b CD45 CD56 CD56+ cellular COVID-19 patients Critically ill cytokine death elevated exhibited expression Host IFNγ indicated Inflammatory inflammatory cell inflammatory cell infiltration inflammatory cells Inflammatory cytokine Inflammatory cytokine storm inflammatory factor storm inflammatory storm inhibited Intervention involved KEGG LPS lung tissue manifested metabolism metabolite mice microbiota microorganism microorganisms modulating mononuclear cell mononuclear cells mRNA mRNAs overlapping Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Protein pulmonary microbiota qPCR reduce reduced Research rRNA S protein SARS-CoV-2 (COVID-19) spike protein SARS-CoV-2 spike SARS-CoV-2 spike protein Secondary Metabolite severely and critically ill COVID-19 patients significantly Streptococcus the S protein the SARS-CoV-2 translation unique [DOI] 10.7150/ijbs.63329 PMC 바로가기 [Article Type] Research Paper
Cardiovascular disease during the COVID-19 pandemic: Think ahead, protect hearts, reduce mortalityArticle Published on 2020-11-062023-06-16 Journal: Cardiology journal [Category] MERS, SARS, [키워드] angiotensin converting enzyme 2 cardiovascular complications COVID-19 Endotheliitis inflammatory factor storm Online consultation [DOI] 10.5603/CJ.a2020.0101 PMC 바로가기